The method
The TARGET System
A six-step approach to adverse events — designed to keep patients on treatment instead of reducing or interrupting their dose.
What it is
Turn adverse events from a reason to stop into something you can control
The TARGET System is a structured, six-step method for managing the side effects of cancer therapy. I developed it for the mucocutaneous adverse events of targeted agents — but the same logic can be applied to almost any adverse event.
Its goal is simple and specific: bring side effects under control without reaching first for dose reduction or interruption — ideally getting a reaction under control within around 48 hours.
The six steps
T · A · R · G · E · T
Terminology
Define the adverse event precisely. Shared language is the foundation of everything that follows.
Assessment
Systematically evaluate what the patient is experiencing, not just what the protocol expects.
Reporting
Record adverse events consistently across clinic and research so nothing gets lost.
Grading
Score severity in a way that actually guides the response — not just a number for the file.
Education
Prepare patients and teams in advance, so early signs are recognised and acted on.
Treatment
Intervene early and appropriately to keep the patient on their planned therapy.
Go deeper
The TARGET System Book
In The TARGET System Book (IMPAQTT, 2014) I set out the full six-step approach and the thinking behind it, illustrated through the mucocutaneous adverse events of targeted therapy. It is both a method and an account of what it takes to become an adverse-event expert.
Who it’s for
Built for the people at the sharp end of care
Oncology & nursing teams
A shared, practical language and workflow for preventing and managing side effects at the bedside.
Research & trial teams
Consistent terminology, reporting and grading that stands up in clinical protocols.
Homecare & industry
A framework to carry expertise beyond the hospital as more cancer care moves into the home.
Bring the TARGET System to your team.
Accredited training, masterclasses and implementation support — tailored to your setting.